Anti-CYE1 [17C8]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CYE1 [17C8]
• Alternate name: CYE-1
• Research fields: Cell biology
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Host: Mouse
• Application: WB ; IF
• Description: Cyclin E is a member of the cyclin family of proteins, which regulates the cell cycle through its activation of cyclin-dependent kinases. Specifically, cyclin E binds and activates the S phase Cdk2. The cyclin E–Cdk2 complex promotes the G1 to S phase cell cycle transition. Overexpression of cyclin E has been implicated in carcinomas among the gastrointestinal tract, including colon or stomach cancer as well as a marker for breast cancers
• Immunogen: Full-length recombinant CYE-1 protein

Target Details

• Target: Cyclin E
• Target background: Cyclin E is a member of the cyclin family of proteins, which regulates the cell cycle through its activation of cyclin-dependent kinases. Specifically, cyclin E binds and activates the S phase Cdk2. The cyclin ECdk2 complex promotes the G1 to S phase cell cycle transition. Overexpression of cyclin E has been implicated in carcinomas among the gastrointestinal tract, including colon or stomach cancer as well as a marker for breast cancers

Applications

• Application: WB ; IF

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Shipping at 4° C

References

• Kim et al. 2007. Mol Cell Biol. 27(4):1394-406. PMID: 17145765.
• The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.