Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5′-CAC[GA]TG-3′. Seems to activate the transcription of growth-related genes.
| Inventor | Institute |
|---|---|
| Richard Marais | The Institute of Cancer Research |
| Cat. #: | 153385 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Breast cancer;Gynaecologic cancer;Lung cancer |
| Research Fields: | Apoptosis and autophagy;Cancer;Cell biology;Immunology |
| Application: | IHC ; IF ; IP ; WB |
| Target: | myc |
| Reactivity: | Human |
| Clone: | JAC6 |
| Host: | Rat |
| Class: | Monoclonal |
| Alternate name: | Myc proto oncogene protein; c Myc |
|---|---|
| Product description: | Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 53 kDa |
| Immunogen: | Synthetic peptide, corresponding to amino acids 408-439 of Human c-Myc |
| Target background: | Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Su et al. 2015. J Cell Sci. 128(22):4063-73. PMID: 26430213. Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site. von Philipsborn et al. 2014. Curr Biol. 24(3):242-51. PMID: 24440391. Cellular and behavioral functions of fruitless isoforms in Drosophila courtship. Coleman et al. 2011. J Biol Chem. 286(19):17205-16. PMID: 21454556. Critical role of the beta-subunit CDC50A in the stable expression, assembly, s… |
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