Anti-CD70 [TAN 1-7] mAb

Cat. #151721

Anti-CD70 [TAN 1-7] mAb

Cat. #: 151721

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-5 days

Target: CD70

Class: Monoclonal

Application: ELISA ; FACS ; IF ; Fn

Reactivity: Mouse

Host: Rat


This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.


Institute: University of Southampton

Tool Details
Target Details

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-CD70 [TAN 1-7] mAb
  • Alternate name: CD7 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD27 Ligand; CD27LG; TNFSF7; CD27L; Tumor Necrosis Factor Ligand 8A; Surface Antigen CD7; Ki-24 Antigen; CD7 Antigen; TNLG8A
  • Research fields: Apoptosis and autophagy;Cancer;Immunology;Stem cell biology
  • Clone: TAN 1-7
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Mouse
  • Host: Rat
  • Application: ELISA ; FACS ; IF ; Fn
  • Description: Monoclonal antibody directed against CD70 cytokine, capable of blocking the CD70-CD27 interaction involved in B and T cell activation.
  • Immunogen: Recombinant mouse CD70 (extracellular domain, aa residues 41-195)
  • Immunogen uniprot id: O55237
  • Isotype: IgG2a
  • Myeloma used: NS0
  • Recommended controls: Activated dendritic cells

Target Details

  • Target: CD70
  • Tissue cell line specificity: Activated dendritic cells
  • Target background: CD70 is a cytokine that belongs to the tumour necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes and dendritic cells. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 expression is induced upon activation of DCs, indicating that the CD70-CD27 interaction could take place during the activation of naive T cells by DCs. Anti-CD70 is non-depleting and blocks the CD70-CD27 interaction. CD70 expression is thought to play a role in autoimmune disease regulation, and treatment of autoimmune diseases such as rheumatoid arthritis.


  • Application: ELISA ; FACS ; IF ; Fn


  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C


  • Arora et al. 2014. Immunity. 40(1):105-16. PMID: 24412610.
  • A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.
  • Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells.
  • Taraban et al. 2008. J Immunol. 180(7):4615-20. PMID: 18354184.
  • Rowley et al. 2004. J Immunol. 172(10):6039-46. PMID: 15128787.
  • Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo.