Monoclonal antibody directed against CD70 cytokine, capable of blocking the CD70-CD27 interaction involved in B and T cell activation.
| Institute |
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| University of Southampton |
| Cat. #: | 151721 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy;Cancer;Immunology;Stem cell biology |
| Application: | ELISA ; FACS ; IF ; Fn |
| Target: | CD70 |
| Reactivity: | Mouse |
| Clone: | TAN 1-7 |
| Host: | Rat |
| Class: | Monoclonal |
| Alternate name: | CD7 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD27 Ligand; CD27LG; TNFSF7; CD27L; Tumor Necrosis Factor Ligand 8A; Surface Antigen CD7; Ki-24 Antigen; CD7 Antigen; TNLG8A |
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| Product description: | Monoclonal antibody directed against CD70 cytokine, capable of blocking the CD70-CD27 interaction involved in B and T cell activation. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Recombinant mouse CD70 (extracellular domain, aa residues 41-195) |
| Immunogen Uniprot ID: | O55237 |
| Myeloma used: | NS0 |
| Target background: | CD70 is a cytokine that belongs to the tumour necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes and dendritic cells. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 expression is induced upon activation of DCs, indicating that the CD70-CD27 interaction could take place during the activation of naive T cells by DCs. Anti-CD70 is non-depleting and blocks the CD70-CD27 interaction. CD70 expression is thought to play a role in autoimmune disease regulation, and treatment of autoimmune diseases such as rheumatoid arthritis. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Arora et al. 2014. Immunity. 40(1):105-16. PMID: 24412610. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells. Taraban et al. 2008. J Immunol. 180(7):4615-20. PMID: 18354184. Rowley et al. 2004. J Immunol. 172(10):6039-46. PMID: 15128787. Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo. |
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