CD45RA is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 RA regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45 can be expressed as one of several isoforms by alternative splicing of exons that comprise the extracellular domain. CD45RA is […]
| Inventor | Institute |
|---|---|
| Roy Jefferis | University of Birmingham |
| Cat. #: | 153172 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Blood cancer |
| Research Fields: | Cell biology;Immunology;Stem cell biology |
| Application: | FACS ; IHC |
| Target: | Protein tyrosine phosphatase receptor type C |
| Reactivity: | Human |
| Clone: | BU77 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | PTPRC, CD45RA |
|---|---|
| Product description: | CD45RA is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 RA regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45 can be expressed as one of several isoforms by alternative splicing of exons that comprise the extracellular domain. CD45RA is expressed on na??ve T cells, as well as the effector cells in both CD4 and CD8. CD45RA is an isoform of the PTPRC complex which is sel… |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Perpheral Blood B cells |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | CD45RA is a transmembrane tyrosine phosphatase that is present on all leukocytes. CD45 RA regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45 can be expressed as one of several isoforms by alternative splicing of exons that comprise the extracellular domain. CD45RA is expressed on nave T cells, as well as the effector cells in both CD4 and CD8. CD45RA is an isoform of the PTPRC complex which is s… |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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