PTPRC, also know as CD45, is a transmembrane tyrosine phosphatase that is present on all leukocytes. It regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn).
| Inventor | Institute |
|---|---|
| Margaret Goodall ; D.L. Hardie ; Roy Jefferis ; Ian MacLennen | University of Birmingham |
| Cat. #: | 151452 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Immunology;Neurobiology;Stem cell biology;Tissue-specific biology |
| Target: | Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45) |
| Clone: | BU64 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Anti-PTPRC |
|---|---|
| Product description: | PTPRC, also know as CD45, is a transmembrane tyrosine phosphatase that is present on all leukocytes. It regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | RPMI 1640 + 10% FCS |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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