Cat. #151361
Anti-CD45 [2B11]
Cat. #: 151361
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45)
Class: Monoclonal
Application: FACS ; IHC ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Karen Pulford
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD45 [2B11]
- Alternate name: Protein Tyrosine Phosphatase Receptor Type C (PTPRC); L-CA; T2; Polypeptide; T2 Leukocyte Common Antigen; Leukocyte Common Antigen; T2 Glycoprotein; GP18; CD45R; B22; LCA; LY5
- Research fields: Cell biology;Cell signaling and signal transduction;Immunology;Neurobiology;Stem cell biology;Tissue-specific biology
- Clone: 2B11
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IHC ; WB
- Description: 2B11 is widely used, in conjunction with the CD45RB antibody PD7/26, to detect white cell-derived tumours in paraffin sections.
- Immunogen: T cell Lymphoma cells
- Isotype: IgG1 kappa
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45)
- Target background: PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn).
Applications
- Application: FACS ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Chijiwa et al. 2015. Int J Oncol. :. PMID: 25963555.
- Tsuneki et al. 2015. Lab Invest. :. PMID: 25961170.
- A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway.
- Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.
- Gatter et al. 1984. Am J Clin Pathol. 82(1):33-43. PMID: 6741874.
- The differential diagnosis of routinely processed anaplastic tumors using monoclonal antibodies.
- Warnke et al. 1983. N Engl J Med. 309(21):1275-81. PMID: 6355845.
- Diagnosis of human lymphoma with monoclonal antileukocyte antibodies.
- Gatter et al. 1983. J Biol Response Mod. 2(4):369-95. PMID: 6196454.
- Monoclonal antibodies in diagnostic pathology: techniques and applications.
