CD44 is an integral cell membrane glycoprotein that binds to hyaluronan and is involved in matrix adhesion, lymphocyte activation, and lymph node homing. The CD44 protein is expressed as a family of molecular isoforms generated from alternative RNA splicing and posttranslational modifications.
| Inventor | Institute |
|---|---|
| David Simmons | University of Oxford |
| Cat. #: | 151573 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction;Immunology |
| Application: | FACS ; IHC ; IP ; WB |
| Target: | CD44v3-10-Fc |
| Reactivity: | Human |
| Clone: | 2F10 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD44 Molecule; Hematopoietic Cell E- And L-Selectin Ligand; GP9 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CSPG8; HCELL; PGP-1; MC56; Pgp1 |
|---|---|
| Product description: | CD44 is an integral cell membrane glycoprotein that binds to hyaluronan and is involved in matrix adhesion, lymphocyte activation, and lymph node homing. The CD44 protein is expressed as a family of molecular isoforms generated from alternative RNA splicing and posttranslational modifications. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | CD44v3-10-Fc Human chimeric fusion protein |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | CD44 is an integral cell membrane glycoprotein that binds to hyaluronan and is involved in matrix adhesion, lymphocyte activation, and lymph node homing. The CD44 protein is expressed as a family of molecular isoforms generated from alternative RNA splicing and posttranslational modifications. |
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| Format: | Liquid |
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| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124. Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms. |
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