Anti-CD195 [HEK/1/85a/7a]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CD195 [HEK/1/85a/7a]
• Alternate name: Anti-CCR5, CCR5 Antibody, CD195 Antibody, C-C chemokine receptor type 5, HIV-1 fusion co-receptor
• Research fields: Immunology;Microbiology
• Clone: HEK/1/85a/7a
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Human
• Host: Rat
• Application: FACS ; IF ; Fn
• Description: CD195 or CCR5 (CC-chemokine receptor type 5) is a receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. It may play a role in the control of granulocytic lineage proliferation or differentiation, and has been shown to act as a co-receptor for HIV-1 R5 isolates. Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
• Immunogen: CHO cells transfected with human CCR5
• Isotype: IgG2a kappa
• Myeloma used: Y3.AG.1.2.3

Target Details

• Target: CD195
• Target background: CD195 or CCR5 (CC-chemokine receptor type 5) is a receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. It may play a role in the control of granulocytic lineage proliferation or differentiation, and has been shown to act as a co-receptor for HIV-1 R5 isolates. Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.

Applications

• Application: FACS ; IF ; Fn

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Mueller et al. 2002. Blood. 99(3):785-91. PMID: 11806977.
• Pathways for internalization and recycling of the chemokine receptor CCR5.