Anti-CD18 [BU86]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CD18 [BU86]
• Alternate name: Cell differentiation 18; Integrin beta-2; ITGB2 gene
• Research fields: Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology
• Clone: BU86
• Class: Monoclonal
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC
• Description: The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form and these ligand binding proteins are inversely associated with disease activity in the autoimmune disease spondyloarthritis.
• Isotype: IgG1

Target Details

• Target: CD18
• Target background: The CD18 protein is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of alpha and beta chains. A given chain may combine with multiple partners resulting in different integrins. In humans a lack of CD18 causes leukocyte adhesion deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. The beta 2 integrins have also been found in a soluble form and these ligand binding proteins are inversely associated with disease activity in the autoimmune disease spondyloarthritis.

Applications

• Application: FACS ; IHC

Handling

• Format: Liquid
• Concentration: 0.9-1.1mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Leucocyte Typing VI, (1998): edited by T. Kishimoto, Garland Publishing, New York.