#158407

Anti-calcium-sensing receptor [HL1499]

Cat. #158407

Anti-calcium-sensing receptor [HL1499]

Cat. #: 158407

Sub-type: Primary antibody

Unit size: 100 ug

Target: Calcium Sensing Receptor (CaSR)

Class: Monoclonal

Application: WB ; IHC ; IP

Reactivity: Human ; Mouse ; Rat ; Rabbit

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: R. Tyler Miller

Institute: University of Florida Research Foundation

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-calcium-sensing receptor [HL1499]
  • Alternate name: CaSR, CaR
  • Research fields: Cell signaling and signal transduction;Tissue-specific biology
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human ; Mouse ; Rat ; Rabbit
  • Host: Mouse
  • Application: WB ; IHC ; IP
  • Description: Calcium-sensing receptor (CaSR) is a GPCR sensing extracellular levels of calcium ions and is primarily expressed in the renal tubes of the kidney and in the parathyroid gland. Mutations have been known to cause several disorders such as familial hypocalciuris hypercalemia, autosomal dominant hypocalcemia and Type 6 Bartter syndrome. CaSR has also been shown to be involved in Alzheimer's Disease, asthma, and cancer. CaSR has been shown to interaction with filamin, which is not present in certain types of cancers, and can only activate ERK in the presence of filamin.
  • Immunogen: Synthetic peptide corresponding to amino acids 15-29 in the extracellular amino terminus of human CaSR
  • Isotype: IgG1 kappa

Target Details

  • Target: Calcium Sensing Receptor (CaSR)
  • Target background: Calcium-sensing receptor (CaSR) is a GPCR sensing extracellular levels of calcium ions and is primarily expressed in the renal tubes of the kidney and in the parathyroid gland. Mutations have been known to cause several disorders such as familial hypocalciuris hypercalemia, autosomal dominant hypocalcemia and Type 6 Bartter syndrome. CaSR has also been shown to be involved in Alzheimer's Disease, asthma, and cancer. CaSR has been shown to interaction with filamin, which is not present in certain types of cancers, and can only activate ERK in the presence of filamin.

Applications

  • Application: WB ; IHC ; IP

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Storage conditions: -20° C
  • Shipping conditions: Shipping at 4° C

References

  • Awata et al. 2001. J Biol Chem. 276(37):34871-9. PMID: 11390379.