Anti-BLM [BFL 103]

BLM is the product of the Blooms syndrome gene and belongs to the RecQ family of DNA helicases. BLM is associated with an increase in the incidence of many types of cancer at an early age.

Contributors

Inventor Institute
Helen Turley University of Oxford
Cat. #: 151267
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics
Application: WB ; ELISA ; IHC ; IF ; WB
Target: Bloom's Syndrome Protein (BLM)
Reactivity: Human
Clone: BFL 103
Host: Mouse
Class: Monoclonal
Product description: BLM is the product of the Blooms syndrome gene and belongs to the RecQ family of DNA helicases. BLM is associated with an increase in the incidence of many types of cancer at an early age.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Recombinant Full Length Bloom's Protein
Myeloma used: P3/NS1/1-Ag4.1
Target background: BLM is the product of the Blooms syndrome gene and belongs to the RecQ family of DNA helicases. BLM is associated with an increase in the incidence of many types of cancer at an early age.
Format: Liquid
Concentration: 0.9 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Chen et al. 2019. Mol Med Rep. 19(6):4819-4831. PMID: 30957187.

Zhu et al. 2008. J Biol Chem. 283(43):29405-15. PMID: 18708356.

Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.

Turley et al. 2001. Br J Cancer. 85(2):261-5. PMID: 11461087.

The distribution and expression of the Bloom's syndrome gene product in normal and neoplastic human cells.

Wu et al. 2000. J Biol Chem. 275(13):9636-44. PMID: 10734115.

The Bloom's syndrome gene product interacts with topoisomerase III.

Images

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Chen et al. Molecular Medicine REPORTS 19

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