Anti-BLK [BLK154/D4]

BLK also stimulates insulin synthesis and secretion in response to glucose by up regulating pancreatic beta-cell transcription factors.

Contributors

Inventor Institute
Jacqueline Cordell University of Oxford
Cat. #: 151789
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy
Application: WB
Target: BLK
Reactivity: Human
Clone: BLK154/D4
Host: Mouse
Class: Monoclonal
Product description: B lymphoid tyrosine kinase is a member of the src family of proto-oncogenes that are involved in cell proliferation and differentiation1. It is expressed in B cells during all stages of development and has a role in B-cell receptor signaling and B-cell development2,3. BLK also stimulates insulin synthesis and secretion in response to glucose by up regulating pancreatic beta-cell transcription factors.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Recombinant protein corresponding to amino acids 53- 224 of human BLK
Myeloma used: NS0
Target background: B lymphoid tyrosine kinase is a member of the src family of proto-oncogenes that are involved in cell proliferation and differentiation1. It is expressed in B cells during all stages of development and has a role in B-cell receptor signaling and B-cell development2,3. BLK also stimulates insulin synthesis and secretion in response to glucose by up regulating pancreatic beta-cell transcription factors.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Borowiec et al. 2009. Proc Natl Acad Sci U S A. 106(34):14460-5. PMID: 19667185.

Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.

Wasserman et al. 1995. J Immunol. 155(2):644-51. PMID: 7608542.

Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement.

Islam et al. 1995. J Immunol. 154(3):1265-72. PMID: 7822795.

Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.

Yao et al. 1993. Proc Natl Acad Sci U S A. 90(17):7946-50. PMID: 7690139.

Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.

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