Anti-ADAM19 [19MOCYT]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-ADAM19 [19MOCYT]
• Research fields: Cancer;Cell signaling and signal transduction
• Clone: 19MOCYT
• Tool sub type: Primary antibody
• Class: Polyclonal
• Conjugation: Unconjugated
• Molecular weight: ~120 kDa
• Reactivity: Mouse
• Host: Rabbit
• Application: WB
• Description: ADAM19, is a member of the ADAM (a disintegrin and metalloprotease-like domain) family. It has been cloned from mouse and human. ADAM19 was first described in muscle cells as a protein with homology to the fertilins (ADAMs 1 and 2). Initial observations indicated a role for ADAM19 in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Later works describe ADAM19 in the bone, muscle, lung, heart, brain, kidney, and a wide range of tissues. Also reported is a sequence of ADAM19 lacking the transmembrane and cytoplasmic domains, suggesting that a soluble form is produced. Other ADAMs family members (ADAM-10, ADAM-17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions.
• Immunogen: GST-fusion protein with the cytoplasmic domain of murine ADAM19

Target Details

• Target: ADAM19
• Molecular weight: ~120 kDa
• Target background: ADAM19, is a member of the ADAM (a disintegrin and metalloprotease-like domain) family. It has been cloned from mouse and human. ADAM19 was first described in muscle cells as a protein with homology to the fertilins (ADAMs 1 and 2). Initial observations indicated a role for ADAM19 in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Later works describe ADAM19 in the bone, muscle, lung, heart, brain, kidney, and a wide range of tissues. Also reported is a sequence of ADAM19 lacking the transmembrane and cytoplasmic domains, suggesting that a soluble form is produced. Other ADAMs family members (ADAM-10, ADAM-17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions.

Applications

• Application: WB

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: Whole serum
• Storage conditions: -20° C
• Shipping conditions: Dry ice

References

• Chesneau et al. 2003. J Biol Chem. 278(25):22331-40. PMID: 12682046.
• Inoue et al. 1998. J Biol Chem. 273(7):4180-7. PMID: 9461614.
• Kawaguchi et al. 2007. J Cell Sci. 120(Pt 6):943-52. PMID: 17344430.
• Zhou et al. 2004. Mol Cell Biol. 24(1):96-104. PMID: 14673146.