Anti-ADAM19 [19MOCYT]

Initial observations indicated a role for ADAM19 in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Later works describe ADAM19 in the bone, muscle, lung, heart, brain, kidney, and a wide range of tissues.

Contributors

Inventor Institute
Carl Blobel Hospital for Special Surgery
Cat. #: 152534
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell signaling and signal transduction
Application: WB
Target: ADAM19
Reactivity: Mouse
Clone: 19MOCYT
Host: Rabbit
Class: Polyclonal
Product description: ADAM19, is a member of the ADAM (a disintegrin and metalloprotease-like domain) family. It has been cloned from mouse and human. ADAM19 was first described in muscle cells as a protein with homology to the fertilins (ADAMs 1 and 2). Initial observations indicated a role for ADAM19 in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Later works describe ADAM19 in the bone, muscle, lung, heart, brain, kidney, and a wide range of tissues. Also reported is a sequence of ADAM19 lacking the transmembrane and cytoplasmic domains, suggesting that a soluble form is produced. Other ADAMs family members (ADAM-10, ADAM-17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions.
Conjugation: Unconjugated
Molecular weight: ~120 kDa
Immunogen: GST-fusion protein with the cytoplasmic domain of murine ADAM19
Target background: ADAM19, is a member of the ADAM (a disintegrin and metalloprotease-like domain) family. It has been cloned from mouse and human. ADAM19 was first described in muscle cells as a protein with homology to the fertilins (ADAMs 1 and 2). Initial observations indicated a role for ADAM19 in myoblast fusion, similar to sperm-egg fusion aided by ADAMs 1 and 2. Later works describe ADAM19 in the bone, muscle, lung, heart, brain, kidney, and a wide range of tissues. Also reported is a sequence of ADAM19 lacking the transmembrane and cytoplasmic domains, suggesting that a soluble form is produced. Other ADAMs family members (ADAM-10, ADAM-17) have been more thoroughly studied, and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: Whole serum
Storage conditions: -20° C
Shipping conditions: Dry ice
References:

Chesneau et al. 2003. J Biol Chem. 278(25):22331-40. PMID: 12682046.

Inoue et al. 1998. J Biol Chem. 273(7):4180-7. PMID: 9461614.

Kawaguchi et al. 2007. J Cell Sci. 120(Pt 6):943-52. PMID: 17344430.

Zhou et al. 2004. Mol Cell Biol. 24(1):96-104. PMID: 14673146.

Images

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Western blot analysis of mouse primary osteoblasts probed with whole ADAM19 antiserum at a 1

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