#153458

pRSF-1b-UbcH5B Vector

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Cat. #153458

pRSF-1b-UbcH5B Vector

Cat. #: 153458

Sub-type: pRSF-1b

Availability: 3-5 days

Target: UbcH5B

Bacterial Resistance: Kanamycin

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Danny Huang

Institute: Cancer Research UK, Glasgow: The Beatson Institute

Tool Details
Handling
Target Details
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: pRSF-1b-UbcH5B Vector
  • Alternate name: UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2
  • Research fields: Cancer;Cell signaling and signal transduction;Genetics
  • Tool sub type: pRSF-1b
  • Backbone size without insert: 3669
  • Bacterial resistance: Kanamycin
  • Description: Protein modification through ubiquitination is an important cellular mechanism to target abnormal or short-lived proteins for degradation. The process of ubiquitination involves three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family. UbcH5B is involved in the ubiquitination of p53 and two alternatively spliced transcript variants have been discovered which encode distinct isoforms.

Handling

  • Storage conditions: -20° C
  • Shipping conditions: Dry Ice

Target Details

  • Target: UbcH5B

Related Tools

  • Related tools: pGEX4T1-CBL-B Vector

References

  • Dou et al. 2012. Nat Struct Mol Biol. 19(9):876-83. PMID: 22902369.
  • BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.