pRSF-1b-UbcH5B Vector

UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family And is involved in the ubiquitination of p53.

Contributors

Inventor Institute
Danny Huang Cancer Research UK, Glasgow: The Beatson Institute
Cat. #: 153458
Tool sub type: pRSF-1b
Research Fields: Cancer;Cell signaling and signal transduction;Genetics
Target: UbcH5B
Backbone size without insert: 3669
Bacterial resistance: Kanamycin
Alternate name: UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2
Product description: Protein modification through ubiquitination is an important cellular mechanism to target abnormal or short-lived proteins for degradation. The process of ubiquitination involves three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family. UbcH5B is involved in the ubiquitination of p53 and two alternatively spliced transcript variants have been discovered which encode distinct isoforms.
Shipping conditions: Dry Ice
References:

Dou et al. 2012. Nat Struct Mol Biol. 19(9):876-83. PMID: 22902369.

BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

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