#152049

pJEK11 Beta-Synuclein Vector

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Cat. #152049

pJEK11 Beta-Synuclein Vector

Cat. #: 152049

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Contributor

Inventor: Dr Fiona Benson

Institute: Lancaster University

Tool Details
Application Details

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: pJEK11 Beta-Synuclein Vector
  • Research fields: Neurobiology
  • Description: pJEK11 is a derivative of pET15b with the open reading frame encoding the human beta-synuclein (β-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct β-synuclein is expressed as a fusion protein with an N-terminal six His tag.
  • Additional notes: Beta-synuclein is an abundant pre-synaptic phosphoprotein that is found in the brain and is homolgous to alpha-synuclein. Beta-synuclein is distinct from alha-synuclein in that it lacks the majority of the hydrophobic non-amyloid-beta component of the Alzeheimer's disease amyloid region. Due to this beta-synuclein is less likely to form insoluble aggregates when compared to alpha-synuclein. It is thought that beta-synuclein may have a protective role against alpha-synucleinopathies. Beta-synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of alpha-synuclein. It has been postulated that beta-synuclein could act as a physiological inhibitor of α-synuclein aggregation and thus protect the central nervous system from the neurotoxic effects of alpha-synuclein

Application Details

  • Application notes: pJEK11 is a derivative of pET15b with the open reading frame encoding the human beta-synuclein (β-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct β-synuclein is expressed as a fusion protein with an N-terminal six His tag.