#152786

Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)

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Cat. #152786

Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)

Cat. #: 152786

Sub-type: Luminophore

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Contributor

Inventor: Michael Coogan

Institute: Lancaster University

Tool Details
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)
  • Research fields: Cancer;Cell biology
  • Molecular formula: (ReO3N3CO)3ReAgO
  • Tool sub type: Luminophore
  • Description: Ag-1 is a luminescent trimeric, rehenium-based molecular vessel which strongly binds silver ions. Ag-1 displays a large Stokes shift (ca. 200nm) which compares very favourably with large Stokes shift materials such as quantum dots. A distinct pattern of localisation has been observed within the nucleus suggesting nucleolar localisation. This could be useful not only for the ability to image nucleoli, but also suggests applications in radiotherapy as Auger electrons emitted by certain isotopes are often considered to be most effective at killing tumour cells when in close proximity to nucleic acids.
  • Molecular weight: 1735
  • Solubility: DMSO
  • Additional notes: Ag-1: Îť max excitation = 371 nm (broad peak extends into the visible and can be excited at 405 nm in microscopy) Îť max emission = 571; lifetime τ = 21 ns. Ag-1 does not release Ag+ except under forcing conditions, unlike physiological conditions.

Handling

  • Purity: 1735 g/mol
  • Shipping conditions: Dry Ice

References

  • Thorp-Greenwood et al. 2011. Chem Commun (Camb). 47(11):3096-8. PMID: 21311811.