Nucleolar Luminophore Ag-1 Small Molecule (Tool Compound)

Ag-1 is a luminescent trimeric, rehenium-based molecular vessel which strongly binds silver ions.

Contributors

Inventor Institute
Michael Coogan Lancaster University
Cat. #: 152786
Tool sub type: Luminophore
Research Fields: Cancer;Cell biology
Product description: Ag-1 is a luminescent trimeric, rehenium-based molecular vessel which strongly binds silver ions. Ag-1 displays a large Stokes shift (ca. 200nm) which compares very favourably with large Stokes shift materials such as quantum dots. A distinct pattern of localisation has been observed within the nucleus suggesting nucleolar localisation. This could be useful not only for the ability to image nucleoli, but also suggests applications in radiotherapy as Auger electrons emitted by certain isotopes are often considered to be most effective at killing tumour cells when in close proximity to nucleic acids.
Additional notes: Ag-1: λ max excitation = 371 nm (broad peak extends into the visible and can be excited at 405 nm in microscopy) λ max emission = 571; lifetime τ = 21 ns. Ag-1 does not release Ag+ except under forcing conditions, unlike physiological conditions.
Molecular weight: 1735
Shipping conditions: Dry Ice
Solubility: DMSO
References:

Thorp-Greenwood et al. 2011. Chem Commun (Camb). 47(11):3096-8. PMID: 21311811.

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