Cat. #161688
Carbazole derivative HV-118
Cat. #: 161688
Availability: 3-4 weeks
Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Cornelis Vlaar
Institute: University of Puerto Rico
Primary Citation: Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: Carbazole derivative HV-118
- Cancer: Breast cancer
- Research fields: Cancer
- Primary target: Rac
- Secondary targets: Rac 1
- Description: Carbazole derivative HV-118 is a highly potent novel anti-cancer and anti-metastatic carbazole derivative. Carbozole derivatives based on EHop-016 generated to mimic the ‘U-shaped’ conformation adopted by EHop-016 as it binds Rac2
- Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
- Purpose: Designed to mimic the 'U-shaped' conformation adopted by EHop-016 as it binds Rac1
Target Details
- Primary target: Rac
- Secondary targets: Rac 1
- Ic50: 100 nM
Application Details
- Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
References
- Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027
