Fibroblast specific Spag17 knockout mouse Product

[…] was created with inducible fibroblast specific Spag17 knockout. Knockout Spag17 mice show significant fibrosis in skin, heart, lungs, kidneys, and skeletal muscle between 4-6 months of age. These mice have […]

PNPLA1 Knockout mouse Product

Useful model to study PNPLA1-deficient deficiency. Animals might be useful for studies, e.g. on skin development/barrier function or omega-O-acylceramide metabolism, or as model for Autosomal Recessive Congenital Ichthyosis (ARCI). Mice […]

Late cornified envelope (LCE)3 protein peptide recognition pattern. (a) Affinity data of anti?LCE3 monoclonal antibody against different LCE3 proteins based on enzyme?linked immunosorbent assay (ELISA) analysis; and comparison of the epitope sequences in the LCE3 members. The LCE3B peptide was used for mouse immunization. (b) Immunohistochemical staining of LCE3 proteins in normal human epidermis with the developed anti?LCE3 monoclonal antibody. The picture is representative for the expression in three different skin biopsies. (c) Staining of LCE3 proteins in normal human skin after competition with our anti?LCE3 antibody and LCE peptides. Scale bar = 100 ?m.

Anti-pan-late cornified envelope 3, pan-LCE3 [7] Product

[…] aerobic and anaerobic species) properties. During inflammation they have been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins have been shown to be […]

Anti-P-glycoprotein [UIC2] Product

[…] colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.

Anti-AvW-5 (von Willebrand Factor) [MBC 121.1] Product

[…] factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding.

Anti-Melanoma cells [NKIM6] Product

[…] men they are most common on the back. Sometimes they develop from a mole with changes such as an increase in size, irregular edges, change in colour, itchiness, or skin breakdown.

TERT-N-HSF cell line Product

Used as immortal human fibroblast line. useful for researchers studying diseases of the skin as they pertain to pathogenesis and inflammation

HFK clone 22 cell line Product

foreskin keratinocytes; Used as an immortal neonatal human skin keratinocyte line for pathogenesis and inflammation studies, transformation

Immunohistochemistry was performed on formalin-fixed; paraffin-embedded breast cancer tissue sections using anti-TMEM2L [V98P4E1*B7] antibody. Strong cytoplasmic and nuclear staining were detected.

Anti-TMEM2L [V98P4E1*B7] Product

[…] intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion […]

Immunofluorescence was performed on human brain cell line (U-138MG) using anti-Cathepsin L [4C11] (A) or a commercially sourced antibody (B)

Anti-Cathepsin L [4C11] Product

[…] cathepsin L is involved in the regulation of epithelial cell proliferation and differentiation in the skin. It is recognized that many cancer cells secrete cathepsin L to degrade the components […]