#160445

Anti-pan-late cornified envelope 3, pan-LCE3 [7]

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Cat. #160445

Anti-pan-late cornified envelope 3, pan-LCE3 [7]

Cat. #: 160445

Sub-type: Primary antibody

Unit size: 100 ug

Target: Late cornified envelope (LCE) protein 3

Class: Monoclonal

Application: ELISA ; IHC ; IF

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Joost Schalkwijk

Institute: Radboud University Medical Center (UMC)

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-pan-late cornified envelope 3, pan-LCE3 [7]
  • Alternate name: Late envelope protein 16, Small proline-rich-like epidermal differentiation complex protein 6A, Small proline-rich-like epidermal differentiation complex protein 6B
  • Research fields: Cell biology;Immunology
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Purpose: Marker
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; IF
  • Description: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defence. They have been shown to posses antibacterial (gram positive and negative, aerobic and anaerobic species) properties. During inflammation they have been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins have been shown to be a significant risk factor in psoriasis.
  • Immunogen: Late cornified envelope protein 3B
  • Myeloma used: Sp2/0

Target Details

  • Target: Late cornified envelope (LCE) protein 3
  • Tissue cell line specificity: Mouse
  • Target background: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defense. They ahve been shown to posses antibacterial (gram positive and negative, aerobic and anearobic speacies) properties. During inflammation they haev been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins has been shown to be a significant risk factor in psoriasis.

Applications

  • Application: ELISA ; IHC ; IF

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • Niehues et al. 2016. Br J Dermatol. 174(4):795-802. PMID: 26556599.