Anti-pan-late cornified envelope 3, pan-LCE3 [7]

Deletion of LCE3B and LCE3C proteins has been shown to be a significant risk factor in psoriasis.

Contributors

Inventor Institute
Joost Schalkwijk Radboud University Medical Center (UMC)
Cat. #: 160445
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Immunology
Application: ELISA ; IHC ; IF
Target: Late cornified envelope (LCE) protein 3
Reactivity: Human
Host: Mouse
Class: Monoclonal
Alternate name: Late envelope protein 16, Small proline-rich-like epidermal differentiation complex protein 6A, Small proline-rich-like epidermal differentiation complex protein 6B
Product description: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defence. They have been shown to posses antibacterial (gram positive and negative, aerobic and anaerobic species) properties. During inflammation they have been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins have been shown to be a significant risk factor in psoriasis.
Conjugation: Unconjugated
Immunogen: Late cornified envelope protein 3B
Myeloma used: Sp2/0
Target background: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defense. They ahve been shown to posses antibacterial (gram positive and negative, aerobic and anearobic speacies) properties. During inflammation they haev been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins has been shown to be a significant risk factor in psoriasis.
Format: Liquid
Shipping conditions: Dry ice
References:

Niehues et al. 2016. Br J Dermatol. 174(4):795-802. PMID: 26556599.

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