Anti-TMEM2L [V98P4E1*B7]

TMEM2L mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid.

Contributors

Inventor Institute
Ayham Alnabulsi Vertebrate Antibodies Limited
Cat. #: 152769
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology
Application: ELISA ; IHC
Target: Cell migration-inducing and hyaluronan-binding protein
Reactivity: Human
Clone: V98P4E1*B7
Host: Mouse
Class: Monoclonal
Alternate name: CEMIP, KIAA1199, CCSP1, IR2155535, Protein KIAA1199, TMEM2L
Product description: TMEM2L mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epitheli…
Conjugation: Unconjugated
Isotype: IgG1 kappa
Molecular weight: 153 kDa (isoform 1), 110 kDa (isoform 2)
Immunogen: Peptide Sequence VTLDTEDHKA peptide immunogen is identical in horse (Equus caballus), 90% identical in mouse (Mus musculus) and rat (Rattus norvegicus)
Myeloma used: P3X63Ag8.653
Target background: TMEM2L mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epitheli…
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

Images

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Immunohistochemistry was performed on formalin-fixed; paraffin-embedded breast cancer tissue sections using anti-TMEM2L [V98P4E1*B7] antibody. Strong cytoplasmic and nuclear staining were detected.

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