The PD-1 protein is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.
Proliferating cell nuclear antigen (PCNA)- Associated Factor (PAF15) is a small protein containing a PCNA interacting motif and sequences for association with ubiquitin enzymes. In interaction with PCNA, PAF15 plays […]
[…] extent and intensity of SPAG1 expression has been shown to be associated with stage and tumour nodal status and this has led to the suggestion that SPAG1 is a novel […]
[…] T cell recognition by abrogating MHC-I antigen presentation. Deficiency in processing components, like the transporter associated with antigen processing (TAP), results in strongly decreased surface display of peptide/MHC-I complexes. A […]
CEACAM6 is a glycosyl phosphatidyl inositol (GPI) linked glycoprotein. CEACAM6 expression is upregulated in many adenocarcinomas and leukemias. CEACAM6 is expressed in epithelial cells of the fetal and adult gastrointestinal…
Kaposi’s sarcoma- associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi’s sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be […]
[…] (also known as D5) is capable of precipitating labelled human cytosolic RE complexes from breast tumour, fibroid, myometrial and endometrial preparations, but does not react with nuclear RE from human […]
[…] T cell recognition by abrogating MHC-I antigen presentation. Deficiency in processing components, like the transporter associated with antigen processing (TAP), results in strongly decreased surface display of peptide/MHC-I complexes. A […]
[…] has been developed using ORF26 protein as an antigen and has demonstrated broad applicability in helping to discern distinct subpopulations of KSHV associated viral particles at various stages of virion assembly.
Release of the soluble form, ME20-S, could protect tumour cells from antibody mediated immunity.
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