CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CR2 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CR2 expression is also gradually lost after stimulation of B cells in vitro.
[…] containing alpha integrin combines with the beta 2 chain to form the integrin lymphocyte function- associated antigen-1 expressed on all leukocytes and this plays a central role in leukocyte intercellular […]
[…] and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens. Integrin beta 1 is expressed as at least four different isoforms. In cardiac muscle […]
[…] alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function- associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in […]
[…] alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function- associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in […]
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