CEACAM6 is a glycosyl phosphatidyl inositol (GPI) linked glycoprotein. CEACAM6 expression is upregulated in many adenocarcinomas and leukemias. CEACAM6 is expressed in epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes.
| Inventor | Institute |
|---|---|
| Bernhard B. Singer | LeukoCom |
| Cat. #: | 153324 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Digestive / Gastrointestinal cancer |
| Research Fields: | Immunology |
| Application: | ELISA ; FACS ; IHC ; WB |
| Target: | CEACAM6, CD66c |
| Reactivity: | Human |
| Clone: | 1H7-4B |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD66c |
|---|---|
| Product description: | CEACAM6 is a glycosyl phosphatidyl inositol (GPI) linked glycoprotein. CEACAM6 expression is upregulated in many adenocarcinomas and leukemias. CEACAM6 is expressed in epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 90 kDa |
| Immunogen: | Recombinant human CEACAM6 extracellular domain. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | CEACAM6 is a glycosyl phosphatidyl inositol (GPI) linked glycoprotein. CEACAM6 expression is upregulated in many adenocarcinomas and leukemias. CEACAM6 is expressed in epithelial cells of the fetal and adult gastrointestinal tract, epithelia of glandular tissues, squamous epithelial cell of the tongue, esophagus and cervix as well as on granulocytes. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Singer et al. 2014. PLoS One. 9(4):e94106. PMID: 24743304. Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses. Muturi et al. 2013. PLoS One. 8(9):e74654. PMID: 24040308. Tumor and endothelial cell-derived microvesicles carry distinct CEACAMs and influence T-cell behavior. Klaile et al. 2013. Respir Res. 14:85. PMID: 23941132. Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II int |
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