Zc3h13-AID cell line

Murine embryonic stem cells with an inducible and reversible KO of Zc3h13

Contributors

Institute
Institut Curie
Cat. #: 162157
Tool sub type: Primary
Research Fields: Stem cell biology
Organism: Mouse
Tissue: Blastocyst
Gender: Male
Model: Genetically modified cell line; Knock in
Growth properties: Adherent
Primary citation: Tomasz Chelmicki et. al. 2021 Nature. 591(7849):312-316. PMID: 33442060
Product description: Murine embryonic stem cells with an inducible and reversible (via degron AID) KO of Zc3h13 – protein used for m6A methylation of RNA
Gender: Male
CRISPR: Yes
Conditional description: Depletion is achieved upon Auxin treatment (degradation of the AID-tagged proteins)
Parental cell line: E14 murine ES cells (129Ola strain)
Model description: The cell line contains OsTIR1 at the TIGRE locus. The AID tag is inserted in the N terminus of the Zc3h13 gene.
Format: Frozen
Shipping conditions: Dry ice
Temperature: 37° C
Atmosphere: 5% CO2
References:

Tomasz Chelmicki et. al. 2021 Nature. 591(7849):312-316. PMID: 33442060

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Zc3h13-AID cell line

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