RMA-S.Trh4 cells

This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo-antigen selectively presented by cells through various pathways. RMA-S lymphoma cells are TAP-deficient on account of an incomplete TAP2 chain, whereas RMA cells have their TAP chain intact.

Contributors

Inventor Institute
Thorbald Van Hall Leiden University and Leiden University Medical Center; Stichting Oncode Institute
Cat. #: 157675
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Blood cancer
Research Fields: Cancer
Organism: Mouse
Tissue: Lymphatic Tissue
Model: Tumour line
Cancer Types In Detail: Mouse Leukemia
Product description: This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo-antigen selectively presented by cells through various pathways. RMA-S lymphoma cells are TAP-deficient on account of an incomplete TAP2 chain, whereas RMA cells have their TAP chain intact.The Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line presents said Trh4…
Production details: Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct
Cellosaurus ID: CVCL_2180
Parental cell line: RMA-S
disease: Cancer
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Recommended controls: RMA.Trh4 cells
Mycoplasma free: Yes
Biosafety level: 1
References:

Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.

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