R-3327-AT6.1 cell line

The cell line may also be used to screen for drugs that target the human tumor suppressor genes expressed. Such drugs can potentially be used as chemotherapeutic or chemopreventive agents for prostate cancer.

Contributors

Inventor Institute
John Isaacs Johns Hopkins University
Cat. #: 156405
Unit size: 1×10^6 cells / vial
Cancer types: Genitourinary cancer
Research Fields: Cancer;Drug development
Model: Cancer Model
Cancer Types In Detail: Prostate
Product description: Somatic cell hybrids created from highly metastatic rat prostatic cancer cells and human chromosome 11 were created using micro cell-mediated chromosome transfer. The introduction of human chromosome 11 into the highly metastatic rat prostate cancer cells suppressed the metastatic ability of the cells without suppression of the in vivo growth rate or tumorigenicity of the hybrid cells.These cell hybrids can be used to pinpoint tumor suppressor genes on human chromosome 11. The cell line may also be used to screen for drugs that target the human tumor suppressor genes expressed. Such drugs can potentially be used as chemotherapeutic or chemopreventive agents for prostate cancer.
Cellosaurus ID: CVCL_4030
disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Ichikawa et al. 1992. Cancer Res. 52(12):3486-90. PMID: 1596907.

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