PKCa cell line

. The MCF7-PKCa cell line was engineered to exogenously overexpress Protein Kinase C alpha (PKCa) which rendered it resistant to tamoxifen. MCF7-PKCa represents a valuable model for tamoxifen resistance and for screening the effectiveness of alternatives.

Contributors

Inventor Institute
Debra Tonetti University of Illinois Chicago
Cat. #: 156372
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Breast cancer
Research Fields: Cancer;Drug development
Organism: Human
Tissue: Breast
Model: Cancer Model
Cancer Types In Detail: Breast cancer;Tamoxifen Resistance
Alternate name: MCF7
Product description: Approximately 70% of breast cancer patients have estrogen receptor positive (ER+) tumors. The selective estrogen receptor modulator (SERM), tamoxifen, and aromatase inhibitors (AIs) represent first-line treatment for ER+ patients however, up to 50% of patients either do not respond or acquire resistance within 5 years of treatment. The MCF7-PKCa cell line was engineered to exogenously overexpress Protein Kinase C alpha (PKCa) which rendered it resistant to tamoxifen. MCF7-PKCa represents a valuable model for tamoxifen resistance and for screening the effectiveness of alternatives.
Additional notes: Engineered to over-express PKCa.
Parental cell line: MCF-7
Disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Xiong et al. 2017. J Med Chem. 60(4):1325-1342. PMID: 28117994.

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