OV4Cis Cell Line

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Cisplatin-resistant OVCAR4-derived HGSC cell line for studying treatment-selected platinum resistance.

Contributors

Inventor Institute
Michelle Lockley Queen Mary University of London, UK
SKU: 161760
Product description: OV4Cis is a cisplatin-resistant derivative of OVCAR4 generated by serial exposure to increasing cisplatin concentrations. It forms part of a characterised panel of platinum-resistant HGSC models developed across OVCAR4, Ovsaho and COV318 backgrounds. Used alongside parental OVCAR4 and other resistant derivatives, OV4Cis supports comparison of cisplatin-selected adaptations within a shared genetic background and across distinct tumour models, helping distinguish recurrent resistance-associated changes from model-specific effects. The wider panel shows transcriptional features overlapping with relapsed human HGSC and retains resistance following drug withdrawal.
Gender: Female
CRISPR: No
Production details: Cells were cultured in vitro in increasing concentrations of either cisplatin or carboplatin until an increase in IC50 between two and ten-fold was achieved to reflect the resistance observed in human patients
Cellosaurus ID: CVCL_E5FN
Parental cell line: OVCAR4 cell lines
Model description: Platinum-resistant HGSC in vivo cell line
Related tools: 161761; 161762; 161763; 161759; 161758
Cat. #: 161760
Provenance and Ownership: The OV4Cis Cell Line is owned by Cancer Research UK. CancerTools supplies the OV4Cis Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing OV4Cis Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Cancer types: Ovarian cancer
Research Fields: Cancer
Organism: Human
Tissue: Ovary
Gender: Female
Model: Mutant
Growth properties: Adherent
Primary citation: J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.
Growth medium: DMEM containing 10% FBS and 1% penicillin/streptomycin. Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained.
Temperature: 37° C
Mycoplasma free: Yes
References:

J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.

Images

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Platinum-resistance can be induced in HGSC cell lines and is maintained after drug withdrawal.

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