Cells were cultured in vitro in increasing concentrations of either cisplatin or carboplatin until an increase in IC50 between two and ten-fold was achieved to reflect the resistance observed in human patients
Parental cell line:
OVCAR4 cell lines
Model description:
Platinum-resistant HGSC in vivo cell line
Cat. #:
161761
Provenance and Ownership:
The OV4Carbo Cell Line is owned by Cancer Research UK. CancerTools supplies the OV4Carbo Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing OV4Carbo Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Cancer types:
Ovarian cancer
Research Fields:
Cancer
Organism:
Human
Tissue:
Ovary
Gender:
Female
Model:
Mutant
Growth properties:
Adherent
Primary citation:
J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.
Growth medium:
DMEM containing 10% FBS and 1% penicillin/streptomycin. Cells should be cultured without drug but used at low passage to ensure drug resistance is maintained.
Temperature:
37° C
Mycoplasma free:
Yes
References:
J I Hoare et al. 2022. Gynecol Oncol. 167(1):96-106. PMID: 35918200.
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