Melan-si4 cell line

Immortal melanocytes derived from Sisi/Sisi, Ink4a-Arf -/- C57BL/6J mice

Contributors

Inventor Institute
Elena Sviderskaya St. George's University London
Cat. #: 162036
Organism: Mouse
Tissue: Skin
Model: Immortalised non-cancerous cell lines
Morphology: Small, oval-fusiform
Product description: The melan-si3, -si-4 and -si5 cell lines are immortal melanocytes derived from Sisi/Sisi, Ink4a-Arf -/- C57BL/6J mice. The silver locus (si) encodes Pmel, a pigment-cell specific protein that forms functional amyloid within melanosomes to enable melanin deposition. These melanocytes retain pigmentation, but melanosomes do not contain Pmel fibrils, thus melanosomes are generally circular in shape. These cells may be useful for the study of early melanosome biogenesis.
Storage conditions: liquid N2

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