Melan-In3 cell line

Immortal melanocyte cell lines derived from the skin of neonatal Mlphln/Mlphln null Ink4aArf -/- C57BL6/J mice

Contributors

Inventor Institute
Elena Sviderskaya St. George's University London
Cat. #: 162016
Organism: Mouse
Tissue: Skin
Model: Immortalised non-cancerous cell lines
Morphology: Small, oval-fusiform
Product description: The melan-ln1, -ln2, ln-3 and ln-4 lines are immortal melanocyte cell lines derived from the skin of neonatal Mlphln/Mlphln null Ink4aArf -/- C57BL6/J mice. The leaden gene product (melanophilin, Mlph) is a Rab27a effector protein involved in melanosome transport and as such, these leaden null melanocytes display perinuclear clustering of pigmented melanosomes. These murine melanocytes are a model of the human disorder Griscelli syndrome in which patients present with hypopigmented skin and hair and immunodeficiencies. These melanocytes are a useful tool for studies of pigmentation genetics and transport of photoprotective eumelanin.
Storage conditions: liquid N2
Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)

Related Tools for Cell lines

Cat. # Tool Name
151448 CMT 167 Cell Line Key Info View Tool
151576 MEF RAF1 KO Cell Line Key Info View Tool
151626 A375P beta6-puro Cell Line Key Info View Tool
151629 MEF Raf1 FF/FF KI Cell Line Key Info View Tool
151631 C-Raf KI D486A Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.