MCF7 ZsGreen-ZNF703 Overexpressing Cell Line

This is a derivative of the MCF7 breast cancer cell line engineered to overexpress Zinc Finger Protein 703 (ZNF703).

Contributors

Inventor Institute
Carlos Caldas University of Cambridge
Cat. #: 157969
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Research Fields: Cancer;Cell signaling and signal transduction
Organism: Human
Tissue: Breast
Model: Knock-In
Growth properties: Adherent
Product description: This is a derivative of the MCF7 breast cancer cell line engineered to overexpress Zinc Finger Protein 703 (ZNF703). ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. Manipulation of ZNF703 expression in the luminal MCF7 cell line modified the effects of TGF? on proliferation. ZNF703 drives the exprsesion of the green fluorescent protein ZsGreen. Please note there is a MCF7 Lenti-control cell line available to use as a negative control with this cell line (see Related tab).
Conditional: No
Parental cell line: MCF7
disease: Cancer
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Recommended controls: MCF7 parental line
Mycoplasma free: Yes
Biosafety level: 1
References:

Holland et al. 2011. EMBO Mol Med. 3(3):167-80. PMID: 21337521.

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