Lysine Specific Demethylase 1 (LSD1) knockout mouse

Using this mouse model it was found that LSD1 regulates the expression and appropriate timing of key developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development.

Contributors

Inventor Institute
Shaun Cowley University of Leicester
Cat. #: 158387
Unit size: 1×10^6 cells / vial
Research Fields: Developmental biology
Model: Knock-Out
Growth properties: gene-trap
Alternate name: LSD1, KDM1A, AOF2, KDM1, KIAA61, LSD1
Product description: Lysine-specific demethylase 1 (LSD1) acts as a coactivator or a corepressor of transcription, depending on the context, of histone H3 through demethylation of both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me). It demethylates mono- and dimethylated histone H3 as part of a larger complex. It essential for embryonic development in the mouse beyond embryonic day 6.5. Using this mouse model it was found that LSD1 regulates the expression and appropriate timing of key developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development.
Conditional: No
Production details: Embryos at the desired developmental stage were produced from timed Lsd1+/Î?‹Â›-geo ?„‚?‚— Lsd1+/Î?‹Â›-geo matings
Disease: Cleft palate, psychomotor retardation, and distinctive facial features (CPRF)
Format: Frozen
Shipping conditions: Dry ice

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