#158387

Lysine Specific Demethylase 1 (LSD1) knockout mouse

Cat. #158387

Lysine Specific Demethylase 1 (LSD1) knockout mouse

Cat. #: 158387

Unit size: 1x10^6 cells / vial

Disease: Cleft palate, psychomotor retardation, and distinctive facial features (CPRF)

Model: Knock-Out

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Shaun Cowley

Institute: University of Leicester

Tool Details
Target Details
Handling

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Lysine Specific Demethylase 1 (LSD1) knockout mouse
  • Alternate name: LSD1, KDM1A, AOF2, KDM1, KIAA61, LSD1
  • Research fields: Developmental biology
  • Disease: Cleft palate, psychomotor retardation, and distinctive facial features (CPRF)
  • Growth properties: gene-trap
  • Model: Knock-Out
  • Conditional: No
  • Description: Lysine-specific demethylase 1 (LSD1) acts as a coactivator or a corepressor of transcription, depending on the context, of histone H3 through demethylation of both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me). It demethylates mono- and dimethylated histone H3 as part of a larger complex. It essential for embryonic development in the mouse beyond embryonic day 6.5. Using this mouse model it was found that LSD1 regulates the expression and appropriate timing of key developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development.
  • Production details: Embryos at the desired developmental stage were produced from timed Lsd1+/Î?‹Â›-geo ?„‚?‚— Lsd1+/Î?‹Â›-geo matings

Target Details

  • Target: Lysine-Specific Demethylase 1

Handling

  • Format: Frozen
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice