Human Imatinib Mesylate-Resistant Leukaemia Cell Line

The human ALL cell line, named BV173, was altered to be imatinib resistant and contains the most frequently observed mutation (E255K) responsible for drug resistance in patients.

Contributors

Inventor Institute
Steven Grant Virginia Commonwealth University
Cat. #: 154032
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Blood cancer
Research Fields: Cancer
Organism: Human
Cancer Types In Detail: Acute Lymphoblastic Leukemia (Ph+ ALL);Chronic Myelogenous Leukemia (CML)
Product description: The human ALL cell line, named BV173, was altered to be imatinib resistant and contains the most frequently observed mutation (E255K) responsible for drug resistance in patients.
Parental cell line: BV173
Disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Cormack et al. 1992. J Mol Biol. 228(4):1078-90. PMID: 1474579.

Structural requirements for the processing of Escherichia coli 5 S ribosomal RNA by RNase E in vitro.

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