CCSP C12 Human Ovarian Cancer subpopulation cell line

The CCSP family of six cell lines aims to recapitulate the ovarian cancer microenvironment, and is suitable for investigation into cancer biology and cancer therapeutics research. These lines are derived from malignant ascites; a common destination for malignant ovarian cancer cells. They have been validated in direct human-to-mouse xenografts (SCID/beige mouse muscle) and human embryonic […]

Contributors

Inventor Institute
Karl Skorecki ; Ehood Katz ; Maty Tzukerman Rambam Health Care Campus
Cat. #: 157959
Unit size: 1×10^6 cells / vial
Cancer types: Gynaecologic cancer
Research Fields: Cancer
Organism: Human
Tissue: Ovary
Model: Tumour line
Cancer Types In Detail: Ovarian
Alternate name: CCSP
Product description: The CCSP family of six cell lines aims to recapitulate the ovarian cancer microenvironment, and is suitable for investigation into cancer biology and cancer therapeutics research. These lines are derived from malignant ascites; a common destination for malignant ovarian cancer cells. They have been validated in direct human-to-mouse xenografts (SCID/beige mouse muscle) and human embryonic stem cell models. The CCSP lines demonstrate morphological hallmarks of ovarian cancer and are positive for clinically relevant ovarian cancer biomarkers CA-125, CA-19.9, and MUC1, as well as the epithelial-specific antigen Ber-EP4. Tumourigenicity has been confirmed for all CCSP sub-populations in the human embryonic stem cell model, and specific sub-populations in the mouse xenograft model.
disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Katz et al. 2009. Clin Cancer Res. 15(1):70-80. PMID: 19118034.

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