Anti-TFF1 [PS2GE2]

pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.

Contributors

Institute
Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151569
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology;Genetics
Application: FACS ; IHC ; IF ; IP ; WB
Target: Trefoil factor 1 (TFF1), also known as pS2
Reactivity: Human
Clone: PS2GE2
Host: Mouse
Class: Monoclonal
Alternate name: BCEI, Breast Cancer Estrogen Inducible Protein, Gastrointestinal Trefoil Protein, Gastrointestinal trefoil protein pS2, HP1A, HPS2, pNR2, TFF1, Trefoil Factor 1Human Entrez Gene ID 731 Human SwissProt P4155 Human Unigene 16287 Human Gene Symbol TFF1Human Chromosome Location 16p11.2
Product description: pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Molecular weight: 6.5 kDa
Immunogen: A synthetic peptide of 28 amino acid residues from the C-terminus of human pS2 protein
Target background: pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Williams R, et al. 1996. Hum Pathol.(12):1259-66.PMID: 8958295

Images

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Formalin-fixed; paraffin-embedded human Breast Carcinoma Stained with pS2 Monoclonal Antibody (GE2).

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