pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours.
| Institute |
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| Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151569 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | FACS ; IHC ; IF ; IP ; WB |
| Target: | Trefoil factor 1 (TFF1), also known as pS2 |
| Reactivity: | Human |
| Clone: | PS2GE2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | BCEI, Breast Cancer Estrogen Inducible Protein, Gastrointestinal Trefoil Protein, Gastrointestinal trefoil protein pS2, HP1A, HPS2, pNR2, TFF1, Trefoil Factor 1Human Entrez Gene ID 731 Human SwissProt P4155 Human Unigene 16287 Human Gene Symbol TFF1Human Chromosome Location 16p11.2 |
|---|---|
| Product description: | pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 6.5 kDa |
| Immunogen: | A synthetic peptide of 28 amino acid residues from the C-terminus of human pS2 protein |
| Target background: | pS2 is a cysteine-rich, 6.5kDa protein found in both oestrogen-dependent (breast tumours) and oestrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localisation to the Golgi apparatus. pS2 is primarily expressed in oestrogen receptor-positive breast tumours. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Williams R, et al. 1996. Hum Pathol.(12):1259-66.PMID: 8958295 |
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