Anti-TCR gamma delta [11F2] monoclonal antibody

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-TCR gamma delta [11F2] monoclonal antibody
• Research fields: Cell signaling and signal transduction;Immunology
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: ELISA ; FACS ; IHC ; IP
• Description: This monoclonal antibody recognises the gamma delta T cell receptor (gamma delta TCR). This antibody can be used to detect populations of gamma delta T cells. This antibody reacts with human gamma delta TCR in native as well as denatured states.
• Immunogen: Purified native TCRg/d
• Isotype: IgG1
• Myeloma used: Sp2/0-Ag14

Target Details

• Target: TCR yd
• Target background: The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognising fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The TCR is composed of two different protein chains. In humans, in 95% of T cells the TCR consists of an alpha chain and a beta chain, whereas in 5% of T cells the TCR consists of gamma and delta (y/d) chains. This ratio changes during ontogeny and in diseased states such as leukaemia, as well as autoimmune diseases like psoriasis.

Applications

• Application: ELISA ; FACS ; IHC ; IP

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Vroom et al. 1991. J Clin Pathol. 44(12):1012-7. PMID: 1838746.
• Bos et al. 1990. J Invest Dermatol. 94(1):37-42. PMID: 1688597.
• Borst et al. 1988. J Exp Med. 167(5):1625-44. PMID: 2966845.