VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells.
| Inventor | Institute |
|---|---|
| Caroline Foxton | Cancer Research Technology |
| Cat. #: | 151409 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Neurobiology |
| Application: | FACS ; IHC ; IF ; WB |
| Target: | Neonatal Nav1.5 (Voltage gated Sodium Channel Nav1.5) |
| Reactivity: | Human |
| Clone: | 4G8:1G7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Molecular weight: | 180-200 kDa |
| Immunogen: | Peptide (14mer) from an extracellular domain of Nav1.5 – VSENIKLGNLSALR |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Vikram et al. 2017. Nat Med. 23(3):361-367. PMID: 28191886. Utrilla et al. 2017. Front Physiol. 8:903. PMID: 29184507. Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436. Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436. Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151015 | Anti-CyclinA [E70.1] |
Key Info
Anti-CyclinA [E70.1]
|
View Tool | |||||||||||||||||||
| 151022 | Anti-IL12 [1-1A4] |
Key Info
Anti-IL12 [1-1A4]
|
View Tool | |||||||||||||||||||
| 151025 | Anti-Vascular endothelium [10] |
Key Info
Anti-Vascular endothelium [10]
|
View Tool | |||||||||||||||||||
| 151029 | Anti-HSVICP8 [11E2] |
Key Info
Anti-HSVICP8 [11E2]
|
View Tool | |||||||||||||||||||
| 151028 | Anti-Cytochrome P450 2C2, 2B1/2 [h7] |
Key Info
Anti-Cytochrome P450 2C2, 2B1/2 [h7]
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.