Anti-LONP1 [LON20/H1]

Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner.

Contributors

Inventor Institute
Helen Turley University of Oxford
Cat. #: 152791
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Genetics;Metabolism
Application: ELISA ; IHC ; WB
Target: Human LON protease
Reactivity: Human
Clone: LON20/H1
Host: Mouse
Class: Monoclonal
Alternate name: hLON, hLON ATP dependent protease, LON, LONP1, lon peptidase 1, mitochondrial, LON protease, Lon protease homolog, Lon protease like protein, Lon protease-like protein
Product description: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner.
Conjugation: Unconjugated
Isotype: IgG
Molecular weight: 106 kDa
Immunogen: KLH-peptide conjugate – N-CEKDDKDAIEEKFRERLKE-C
Target background: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Cameron Edward Snell PhD thesis, (2013). Mitochondrial modulators of hypoxia-related pathways in tumours. DPhil. University of Oxford.

Snell et al., 2016. Targeting the mitochondrial Lon protease reduces aerobic glycolysis and HIF-1a stabilisation in tumour cells. Submitted for publication.

Images

View Gallery
U87 cells were transfected with siRNA against the Lon protease (siLonp1.1 and siLonp1.2) or a control sequence (siControl) or transfection reagent alone (mock) and then western blotted using anti-LONP1 [LON20/H1] and a loading control antibody (?-actin). Molecular weight markers are labelled in kilodaltons

Related Tools for Antibodies

Cat. # Tool Name
151025 Anti-Vascular endothelium [10] Key Info View Tool
151036 Anti-ICAM1 [15.2] Key Info View Tool
151037 Anti-Cdk1 [17 (A17)] Key Info View Tool
151039 Anti-Integrin aVb3 [23C6] Key Info View Tool
151020 Anti-CyclinB1 [V143.1] Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.