Cat. #153965
Anti-HPV-18 E6phospho
Cat. #: 153965
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: HPV E6
Class: Polyclonal
Application: WB
Reactivity: Human papilloma virus
Host: Rabbit
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Lawrence Banks
Institute: International Centre For Genetic Engineering And Biotechnology (ICGEB)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-HPV-18 E6phospho
- Research fields: Microbiology
- Tool sub type: Primary antibody
- Class: Polyclonal
- Conjugation: Unconjugated
- Reactivity: Human papilloma virus
- Host: Rabbit
- Application: WB
- Description: Nearly all cases of cervical cancer are associated with HPV infection, with two types, HPV16 and HPV18, present in 70% of cases. A defining feature of cervical cancers and derived cell lines is the continued expression of two viral oncoproteins, E6 and E7. A defining characteristic of E6 oncoproteins derived from cancer-causing HPV types is the presence of a PDZ binding motif (PBM) at the extreme carboxy terminus of the protein which is absent from E6 proteins derived from the so-called low-risk HPV types. Within this PBM is also a protein kinase A (PKA) phospho-acceptor site, which is thought to negatively regulate the association of E6 with its PDZ domain-containing substrates
- Immunogen: Peptide: RQERLQRRRETQV
Target Details
- Target: HPV E6
- Target background: Nearly all cases of cervical cancer are associated with HPV infection, with two types, HPV16 and HPV18, present in 70% of cases. A defining feature of cervical cancers and derived cell lines is the continued expression of two viral oncoproteins, E6 and E7. A defining characteristic of E6 oncoproteins derived from cancer-causing HPV types is the presence of a PDZ binding motif (PBM) at the extreme carboxy terminus of the protein which is absent from E6 proteins derived from the so-called low-risk HPV types. Within this PBM is also a protein kinase A (PKA) phospho-acceptor site, which is thought to negatively regulate the association of E6 with its PDZ domain-containing substrates
Applications
- Application: WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Storage buffer: Serum
- Shipping conditions: Shipping at 4° C
References
- Boon et al. 2015. J Virol. 89(3):1579-86. PMID: 25410862.
- Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.
- Boon et al. 2013. J Virol. 87(3):1586-95. PMID: 23175360.
- High-risk human papillomavirus E6 oncoproteins interact with 14-3-3 in a PDZ binding motif-dependent manner.
