![SDS-PAGE gel of Anti-Estradiol-17-beta [S16] recombinant antibody in both its reduced and non-reduced state.](https://cancertools.org/wp-content/uploads/f9071b2f-a261-4e7a-8a1d-dc6a90ab7fdd.png)
Cat. #157720
Anti-Estradiol-17-beta [S16] rAb
Cat. #: 157720
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-5 days
Target: Estradiol-12-beta
Class: Recombinant
Application: ELISA ; IF ; IP
Reactivity: Human
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Urpo Lamminmaki
Institute: University of Turku
Primary Citation: Leivo et al. 2019. Anal Bioanal Chem. 411(22):5633-5639. PMID: 31177333.
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Estradiol-17-beta [S16] rAb
- Alternate name: Oestradiol, E2
- Research fields: Developmental biology
- Clone: S16
- Tool sub type: Primary antibody
- Class: Recombinant
- Purpose: Marker
- Conjugation: Unconjugated
- Molecular weight: 145668.74 kDa
- Reactivity: Human
- Application: ELISA ; IF ; IP
- Description: Anti-Estradiol-17-beta [S16] is a high-affinity recombinant antibody specific to oestradiol (E2). E2 is the most potent of the naturally occurring oestrogenic hormones. Detection of circulatory E2 has many uses in various clinical applications. The use of this antibody alongside the anti-estradiol-immunocomplex antibody makes up the basis for an E2 assay which addresses the low circulatory levels of E2 within blood samples (the cause of failure for many similar competitive immunoassays). This recombinant antibody aids in extracting clinical relevant information from circulatory E2 levels, for example during aromatase inhibitor therapy for breast cancer. Please note, if this reagent will be used in a non-competitive immunoassay then you may require a license to the following patent rights which are held by VTT Technical Research Centre of Finland (US7749712B2; EP1579222B1, EP1579222B8, BRPI0316384B1, CN1711476B, JP4729701B2, NO338417B1, ZA200503475B).
- Isotype: IgG1
Target Details
- Target: Estradiol-12-beta
- Molecular weight: 145668.74 kDa
- Target background: Estradiol is an oestrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. With age and in the case of pathologies such as ovarian failure and following surgical removal of the oavries, levels of estradiol can fall. This results in symptoms such as osteoporosis, vaginal changes, changes to the skin and hot flushes. Recombinant anti-estradiol immunocomplex antibody, clone [C6], binds to the immunocomplex of the anti- Estradiol-17-beta antibody clone [S16] and Estradiol-17-beta. For use in the detection of estradiol in low levels.
Applications
- Application: ELISA ; IF ; IP
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-Estradiol immuno complex [C6] recombinant antibody
References
- Leivo et al. 2019. Anal Bioanal Chem. 411(22):5633-5639. PMID: 31177333.
- Kokko et al. 2007. Anal Chem. 79(15):5935-5940. PMID: 17602670.
