Cat. #151862
Anti-Cytochrome P450 3A4 [F24 P2 B10]
Cat. #: 151862
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: CYP3A4 & CYP3A5 Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine 3-monooxigenase)
Class: Monoclonal
Application: ELISA ; IHC ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Cytochrome P450 3A4 [F24 P2 B10]
- Research fields: Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology
- Clone: F24P2B10
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Description: Cytochrome P450 3A4 (CYP3A4) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 expressed mainly in the liver and intestine oxidizes xebiotics that are then removed from the body.
- Immunogen: Ovalbumin-conjugated synthetic peptide ESRDGTVSGA
- Isotype: IgG1 kappa
- Myeloma used: P3X63Ag8.653
- Recommended controls: IHC: formalin-fixed, paraffin-embedded prostate cancer sections. Western blot: recombinant P450 (shown below @ 0.5 pmol per lane). Negative control: Gentest Cat. No M101b.
Target Details
- Target: CYP3A4 & CYP3A5 Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine 3-monooxigenase)
- Tissue cell line specificity: IHC: formalin-fixed, paraffin-embedded prostate cancer sections. Western blot: recombinant P450 (shown below @ 0.5 pmol per lane). Negative control: Gentest Cat. No M101b.
- Target background: Cytochrome P450 3A4 (CYP3A4) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP3A4 expressed mainly in the liver and intestine oxidizes xebiotics that are then removed from the body.
Applications
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Murray et al. 2010. Histopathology. 57(2):202-11. PMID: 20716162.
- Profiling the expression of cytochrome P450 in breast cancer.
