Monoclonal antibody directed against CR2, involved in allergic responses and inflammatory diseases.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151354 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Immunology |
| Application: | FACS ; IHC |
| Target: | Complement component (3d/Epstein Barr virus) receptor 2 (CR2, CD21) |
| Reactivity: | Human |
| Clone: | 21A/5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Complement Component 3d Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor; EBV Receptor; C3DR; CD21 Antigen; CVID7; SLEB9; CD21; Cr2; CR |
|---|---|
| Product description: | Monoclonal antibody directed against CR2, involved in allergic responses and inflammatory diseases. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | CD21 |
| Immunogen Uniprot ID: | P20023 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | CR2 is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CR2 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CR2 expression is also gradually lost after stimulation of B cells in vitro. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. CR2 binds to CD23 and as… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
CD Guide for CD21 (1989) In Knapp W, et al (eds) Leucocyte Typing IV, Oxford University Press, Oxford, New York and Tokyo, p 1080. ISBN-13: 978-0192618672 |
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