Monoclonal antibody which binds to a specific epitope in complement receptor 1 without effecting complement activity, with use in CR1 quantitation.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151087 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Immunology |
| Application: | IHC ; IP |
| Target: | Complement receptor 1 (CR1, CD35) |
| Reactivity: | Human |
| Clone: | E11 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Hogg et al. 1984. Eur J Immunol. 14(3):236-43. PMID: 6368248. |
| Product description: | Monoclonal antibody which binds to a specific epitope in complement receptor 1 without effecting complement activity, with use in CR1 quantitation. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 130 kDa |
| Immunogen: | Acute monocytic leukaemia cells and normal blood monocytes. |
| Immunogen Uniprot ID: | P17927 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | CR1 is found on many leucocytes and binds C3b and C4b. E11 detects CR1 on most leukemic monoblasts, granulocytes and may be used to define B cell lymphomas. E11 binds to a 222kDa antigen. This antibody is specific for a binding site in CR1 which is distal from the C3b binding site. As such CR1 activity is not blocked. CR1 is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b within the complement system. CR1 is present on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukaemia's, follicular dendritic reticulum cells and is negative on basophils. Anti-CR1 E11 is useful for identifying CR1 on various cells in tissue sections, and for quantitating CR1 on erythrocytes and neutrophils. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Leucocyte Typing III. Edited by AJ McMichael et al. 1987 Lorenzini et al. 2017. Cell Microbiol. 19(9):. PMID: 28346820. Fonseca et al. 2016. PLoS One. 11(2):e0149792. PMID: 26914463. Mahmoudi et al. 2015. Neurobiol Aging. 36(4):1766.e5-1766.e12. PMID: 25666996. Matthews et al. 2008. Dev Dyn. 237(1):124-31. PMID: 18095340. Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish. Hogg et al. 1984. Eur J Immunol. 14(3):236-43. PMID: 6368248. Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1). |
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