Anti-CDX1 [123a]

CDX1 is an intestine-specific transcription factor with a role in directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. Cdx1 positively regulates its own expression in the small intestine and colon of fetus and adult and promotes cellular growth and differentiation in epithelial intestinal cells.

Contributors

Inventor Institute
Walter Bodmer University of Oxford
Cat. #: 151546
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy;Cancer;Genetics
Application: ChIP ; IF ; WB ; ChIP-seq
Target: CDX1
Reactivity: Human
Clone: 123a
Host: Mouse
Class: Monoclonal
Alternate name: Caudal Type Homeobox 1
Product description: CDX1 is an intestine-specific transcription factor with a role in directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. Cdx1 positively regulates its own expression in the small intestine and colon of fetus and adult and promotes cellular growth and differentiation in epithelial intestinal cells. A reduction in human Cdx1 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 32 kDa
Immunogen: Human CDX-1 N-terminal peptide
Myeloma used: P3/NS1/1-Ag4.1
Target background: CDX1 is an intestine-specific transcription factor with a role in directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. Cdx1 positively regulates its own expression in the small intestine and colon of fetus and adult and promotes cellular growth and differentiation in epithelial intestinal cells. A reduction in human Cdx1 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Jones et al. 2015. Proc Natl Acad Sci U S A. 112(13):E1550-8. PMID: 25775580.

The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation.

Ashley et al. 2013. Cancer Res. 73(18):5798-809. PMID: 23867471.

Stem cell differentiation and lumen formation in colorectal cancer cell lines and primary tumors.

Yeung et al. 2011. Proc Natl Acad Sci U S A. 108(11):4382-7. PMID: 21368208.

Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells.

Yeung et al. 2010. Proc Natl Acad Sci U S A. 107(8):3722-7. PMID: 20133591.

Cancer stem cells from colorectal cancer-derived cell lines.

Chan et al. 2009. Proc Natl Acad Sci U S A. 106(6):1936-41. PMID: 19188603.

Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1.

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