The detection of this protein provides important information about cell health and survival.
| Inventor | Institute |
|---|---|
| Sharon Tooze | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151525 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Cancer;Cell signaling and signal transduction;Metabolism;Neurobiology;Tissue-specific biology |
| Application: | IHC ; IP ; ELISA ; IHC ; IF ; IP ; WB |
| Target: | Autophagy-related protein 9 (ATG9) |
| Reactivity: | Human ; Mouse ; Rat |
| Clone: | Atg9 14F2 8B1 |
| Host: | Hamster |
| Class: | Monoclonal |
| Product description: | Autophagy is an important process associated with infectious disease, neurodegeneration, cancer and the maintenance of cellular homeostasis. ATG9 is an essential component of the autophagy machinery and is found on autophagosomes. It is a multi-spanning membrane protein which makes it useful for sub-cellular localization studies. The detection of this protein provides important information about cell health and survival. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 105 kDa |
| Immunogen: | Conserved C-terminal synthetic peptide of Human ATG9 sequence |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | Autophagy is an important process associated with infectious disease, neurodegeneration, cancer and the maintenance of cellular homeostasis. ATG9 is an essential component of the autophagy machinery and is found on autophagosomes. It is a multi-spanning membrane protein which makes it useful for sub-cellular localization studies. The detection of this protein provides important information about cell health and survival. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.7 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase III? Chan et al. 2009. Mol Cell Biol. 29(1):157-71. PMID: 18936157. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. |
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