Anti-AnxA6 [9E1]

MAb 9E1 significantly decreases invasion in pancreatic, lung squamous and breast cancer cells and silencing of its target antigen, which was revealed as AnxA6, leads to markedly reduced invasive capacity of pancreatic and lung squamous cancer in vitro

Contributors

Inventor Institute
Prof Martin Clynes Dublin City University
Cat. #: 161729
Tool sub type: Primary antibody
Cancer types: Breast cancer, Pancreatic cancer, Lung cancer
Research Fields: Cancer
Application: WB, IP, IHC, ELISA
Target: AnxA6 antigen
Reactivity: Human
Clone: 9.00E+01
Host: Mouse
Class: Monoclonal
Primary citation: O'Sullivan D, et al. 2017. Br J Cancer. 1326-1335. PMID: 28881357
Product description: A highly invasive clonal variant of the MDA-MB-435S cell line was used to generate MAb 9E1, which was screened for anti-invasive activity against aggressive cancer cells in vitro.
Conjugation: No
Isotype: IgG1
Target background: Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. AnxA6 is suggested to be functionally involved in the invasive phenotype of PDAC and lung squamous cancer in vitro.
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

O'Sullivan D, et al. 2017. Br J Cancer. 1326-1335. PMID: 28881357

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