RalB Floxed Mouse Product
Ras-related protein Ral-B protein RALB in migration/invasion, tumor cell survival, autophagy and TBK1 activation.
RalA Floxed Mouse Product
Ras-related protein Ral-A protein is encoded on chromosome 7, and has been implicated in insulin secretion, epithelial cell polarity neurite branching, neuronal polarity and GLUT4 translocation
Investigating undruggable targets in cancer research Blog Post
[…] the term is becoming increasingly inaccurate. A few so-called undruggable targets, such as Bcl-2 and RAS, have been successfully targeted with clinically approved inhibitors. Therefore, “difficult to drug” or “yet […]
Pik3cb RBD mutant Mouse Product
[…] and CDC42 (from the RHO subfamily of small GTPases) bind and activate PIK3CB via its RAS binding domain (RBD), but PIK3CB does not bind RAS._x000D_ _x000D_ S205D and K224A point […]
3LL NRAS KO #86 cell line Product
KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog); also known as ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
3LL NRAS KO #63 cell line Product
KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog); also known as ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
RalGDS Floxed Mouse Product
The knock-out mouse was developed by Chris Marshall at the ICR and used to demonstrate a significant role for RalGDS in Ras-dependent carcinogenesis in vivo.
RalGDS KO Mouse Product
Mouse deficient in RalGDS (a member of the RalGEF family, which control the activity of the small GTPases RalA and RalB, and also have Ras binding domains).
Anti-Rheb [Rheb 5D5] Product
Rheb ( Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins. Rheb is expressed at high levels in the brain, […]
RafTR Mouse Product
[…] nervous system (Neurofibromas). These tumours are initiated by Schwann cells in which the small GTPase Ras becomes basally more active. Raf is one of the key downstream effectors of Ras […]
