RalA Floxed Mouse Product

Ras-related protein Ral-A protein is encoded on chromosome 7, and has been implicated in insulin secretion, epithelial cell polarity neurite branching, neuronal polarity and GLUT4 translocation

RalB Floxed Mouse Product

Ras-related protein Ral-B protein RALB in migration/invasion, tumor cell survival, autophagy and TBK1 activation.

RalGDS KO Mouse Product

Mouse deficient in RalGDS (a member of the RalGEF family, which control the activity of the small GTPases RalA and RalB, and also have Ras binding domains).

RalGDS Floxed Mouse Product

The knock-out mouse was developed by Chris Marshall at the ICR and used to demonstrate a significant role for RalGDS in Ras-dependent carcinogenesis in vivo.

Investigating undruggable targets in cancer research Blog Post

[…] the term is becoming increasingly inaccurate. A few so-called undruggable targets, such as Bcl-2 and RAS, have been successfully targeted with clinically approved inhibitors. Therefore, “difficult to drug” or “yet […]

3LL NRAS KO #86 cell line Product

KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog); also known as ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras

3LL NRAS KO #63 cell line Product

KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog); also known as ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras

Pik3cb RBD mutant Mouse Product

[…] and CDC42 (from the RHO subfamily of small GTPases) bind and activate PIK3CB via its RAS binding domain (RBD), but PIK3CB does not bind RAS. S205D and K224A point mutations […]

Anti-Rheb [Rheb 5D5] Product

Rheb ( Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins. Rheb is expressed at high levels in the brain, […]