[…] decades and the term is becoming increasingly inaccurate. A few so-called undruggable targets, such as Bcl-2 and RAS, have been successfully targeted with clinically approved inhibitors. Therefore, “difficult to drug” […]
Monoclonal antibody directed against both isoforms of BCL-2 protein.
Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause […]
Monoclonal antibody which binds anti-apoptotic regulator BCL2, used to aid in differentiating between various lymphomas and as prognostic biomarker in various cancers.
Praf2 is a novel protein involved in endoplasmic reticulum to golgi transport. It has been found up-regulated in several cancers and it has been found to interact with Bcl-xL/Bcl-2
[…] the nucleus and the cytoplasm. Overexpression of BCLAF1 promotes apoptosis by preventing the transcription of Bcl-2. Bcl-2 is one of many key regulators of apoptosis which are essential for development, […]
![Immunohistochemistry using anti-p53 [V5P4H6*B3] on a Zebrafish embryo.](https://cancertools.org/wp-content/uploads/4cba5645-9492-4a6a-aabd-55f0dfe6606b.png)
[…] be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform […]
[…] lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2._x000D_ _x000D_ PD-L1 binds to its receptor, PD-1, found on activated T cells, B cells, […]
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