DLKP-M cell line

The DLKP-M cell line is a mesenchymal-like sub-population cloned at NCTCC from DLKP P5, about 5% of DLKP cells show DLKP-M morphology, interconversion with -I, closest to normal chromosome number, fold resistance comp. to DLKP: 0.8 Adr; 0.95 Vcr; 0.7 VP-16. Immunocytochemistry: cytokeratin (all)-; GFAP-vimentin+; neurofilament+; P-gp-; a2- integrin++; 703D4+; 704A1 +; desmin-. More invasive […]

Contributors

Inventor Institute
Martin Clynes Dublin City University
Cat. #: 157660
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Lung cancer
Research Fields: Cancer
Organism: Human
Tissue: Lung
Growth properties: Monolayer
Cancer Types In Detail: Lung carcinoma
Product description: Mesenchymal-like sub-population cloned at NCTCC from DLKP P5, about 5% of DLKP cells show DLKP-M morphology, interconversion with -I, closest to normal chromosome number, fold resistance comp. to DLKP: 0.8 Adr; 0.95 Vcr; 0.7 VP-16. Immunocytochemistry: cytokeratin (all)-; GFAP-vimentin+; neurofilament+; P-gp-; a2- integrin++; 703D4+; 704A1 +; desmin-. More invasive in vitro than DLKP-SQ.
Production details: Single cell cloning from DLKP parental population
Cellosaurus ID: CVCL_H739
Parental cell line: DLKP
Disease: Cancer
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: DMEM/Ham's F12, 5% FCS. Split 1:5, medium change 2-3 times weekly. Freezing method: 10% DMSO in FBS
Recommended controls: DLKP parental line
Mycoplasma free: Yes
Biosafety level: 1
References:

O'Sullivan et al. 2014. Tumour Biol. 35(7):6983-97. PMID: 24744142.

Keenan et al. 2012. Exp Cell Res. 318(5):593-602. PMID: 22281030.

McBride et al. 1998. Tumour Biol. 19(2):88-103. PMID: 9486560.

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